弱精子症病人精子线粒体DNA4977-bp缺失研究

Study on mitochondrial DNA 4977-bp deletion in asthenospermia sperm.

本文采用聚合酶链反应（ＰＣＲ） 技术对４１ 例标本，其中２０ 例弱精子症病人和２１ 例精子活力正常人进行了精子线粒体ＤＮＡ（ｍｔＤＮＡ）缺失的研究。结果发现２０ 例弱精子症病人中１８ 例有缺失，而２１ 例精子活力正常人中仅有两例有缺失。说明线粒体ＤＮＡ４９７７ｂｐ 缺失在弱精子症的发病中起重要作用。

samples from 20 asthenospermia and 21 normal individls were studied using PCR method.The result showed the deletions of mitochondrial DNA 4977-bp in 18 samples from 20 asthenospermia and in 2 samples from 21 normal individuals. These finding suggest that mitochondrial DNA 4977-bp deletions may play an important role in asthenospermia.