脐血细胞因子水平与胎膜早破宫内感染及新生儿感染的相关研究

Study of cord serum inflammatory cytokines in patients with premature rupture of membranes and evidences of intrauterine infection and in infected infants.

采用双抗体夹心ＥＬＩＳＡ法测定３６ 例正常妊娠妇女及８５ 例胎膜早破患者脐血白细胞介素６（ＩＬ６） 和白细胞介素８（ＩＬ８） 水平。结果发现：胎膜早破合并临床绒毛膜羊膜炎者、病理诊断绒毛膜羊膜炎者及新生儿感染者，其脐血ＩＬ６ 和ＩＬ８ 水平明显高于正常妊娠妇女，胎膜早破未合并感染者及未感染新生儿，差异有显著性意义（Ｐ＜ ０－０１） 。提示：脐血ＩＬ６ 和ＩＬ８ 水平升高可作为胎膜早破合并宫内感染及新生儿感染的指标，用于指导新生儿抗感染治疗。

Cord serm interleukin-6(IL-6) and interleukin-8(IL-8) were determined by a sensitive enzyme-linked immunosorbent assay in 36 normal later pregnanc women and 85 patients with premature rupture of membranes (PROM).Results: The cord serum IL-6 and IL-8 concentrations in patients with PROM and evidence of clinical or histologic chorioamnionitis and in infected infants were higher than those in the normal late pregnancy women, patients with PROM but without infection and in not infected infants. The results showed that cord serum IL-6 and IL-8 can be used as markers for the detection of PROM with intrauterine infection and infection of infants.