高原低氧与循环内皮细胞计数及内皮素-1和心钠素含量的相关性研究

THE RELATIONSHIP OF HYPOXIA ON CIRCULATING ENDOTHELIAL CELL COUNT,CONTENTS OF ENDOTHELIN 1 AND ATRIAL NATRIURETIC PEPTIDE IN SUBJECTS AT HIGH ALTITUDE

目的：探讨高原低氧环境下血管内皮细胞（ＶＥＣ）的损伤情况及功能变化；方法：对从平原（海拔１ ４００ｍ ）进驻海拔３ ７００ｍ （１０ 人）与５ ３８０ｍ （２０ 人）高原第７ 天和半年的青年进行循环内皮细胞计数（ＣＥＣ）、血浆内皮素－１（ＥＴ－１）和心钠素（ＡＮＰ）含量测定，并与平原作对照。结果：在高原缺氧条件下，血浆ＣＥＣ计数和ＥＴ－１、ＡＮＰ含量明显高于平原（Ｐ＜ ０．０１），且随海拔高度的升高而增高（Ｐ＜ ０．０１），初入高原时明显高于在高原居住半年的数值（Ｐ＜ ０．０５ 或Ｐ＜ ０．０１）。在不同海拔高度居住不同时间的ＥＴ－１与ＣＥＣ和ＡＶＰ呈高度正相关；结论：血管活性肽ＥＴ－１、ＡＮＰ分泌可能对急、慢缺氧环境下的心血管系统功能及神经内分泌调节具有重要意义。

To study the damages and functional changs of vascular endothelial cells(VCE) in subjects at high altitude.Methods:To measure the circulating endothlial cells (CEC) count and determine contents of Endothelin (ET 1)as well as atrial natriuretic peptide (ANP) in young men living at 3 700m(10men) or 5 380m(20men) above sea level after staying for seven days or six months.Results:Plasma CEC,ET 1.ANP were sigingificatily higher in subjects at high altitude than those at 1 400m( P <0.01).Subjects at 5 380m showed most obvious changes (P <0.01)Increments of the parameters on the 7th day after arrival were highor markedly than those after staying at high altitude for six months (P <0 05 or P <0.01).It was also found that there were a positive correlation between ET 1 and CEC,ANP at the different sea level and time of exposed to high altitude.Conclusions:The changes in contents of vasoactive peptides,RT 1 and ANP,may play an important roles for regulation of cardiovascular functions at high altitude.$$$$