高原肺水肿患者红细胞促中性粒细胞吞噬功能改变

CHANGE SOF GRANULOCYTE PHAGOCYTOSIS IN HIGH ALTITUDE PULMONARY EDEMA PATIENTS

目的：为了解高原肺水肿（ＨＡＰＥ）发病机理与红细胞免疫之间的关系；方法：观察了４７ 例ＨＡＰＥ患者中性粒细胞吞噬功能及红细胞促中性粒细胞吞噬功能，与３４ 例初入高原健康人和３１例急性高原反应（ＨＡＡＲ）患者进行了比较，探讨了吞噬率、吞噬增强率与ＷＢＣ的关系：结果：ＨＡＰＥ患者吞噬率明显增强，而吞噬增强率则减弱（Ｐ＜０．０１）；吞噬率、吞噬增强率分别与ＷＢＣ呈正负相关（Ｐ＜ ０．０１）；动态观察显示经治疗后红细胞促中性粒细胞吞噬功能可以得到恢复。结论：提示红细胞促中性粒胞吞噬功能的改变与ＨＡＰＥ的发生发展有一定的联系。

To explore the relationship between immune function of erythrocyte and pathogenesis of high altitude pulmonary edema (HAPE).Methods:Three groups of the studies were performed:①A group in which 47 sudjcts with HAPE were used;②A group,31 subjects with acute high altitude reaction (HAAR);③A group,34 subjects served as healthy control.the phagocytic function of granuocyte was determined through its phagocytic rate.Results:The granulocye phagocytic rste of patients with HAPE was increased but the enhanced phagocytic rate of RBC was decreased ( P <0 01).There was a positive correlation between the phagocytic rate and WBC;contrary between enhanced phagocytic rate and WBC ( P <0.01).The changes of phagocytic rate could be retuned on dynamics by therapy.Conclusions:The phathogenesis of HAPE could associated with the granulocyte phagoctic effects and there is an important therapeutic effects on HAPE as increase the immune capacity of RBC.