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非小细胞肺癌患者体内中性粒细胞明胶酶相关脂质运载蛋白和核因子-κB的表达及其与化疗患者预后的相关性 被引量：1

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摘要 中性粒细胞明胶酶相关脂质运载蛋白（neutro-philgelatinase-associated lipocalin,NGAL）是载脂蛋白家族成员,定位于染色体9q34上,与小鼠癌基因产物24p3高度同源[1],可能是人类的一种新的癌基因,近年来受到人们的重视.研究结果显示,NGAL基因在肿瘤组织和细胞系中表达增高,猜测其与肿瘤的发生、发展及预后存在着一定的关系,但其作用机制尚不清楚.
作者 吴秋歌 王静 程哲 蒋军广 苗丽君
机构地区 郑州大学第一附属医院老年呼吸睡眠科河南高等学校临床医学重点学科开放实验室 郑州大学第一附属医院呼吸内二科
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2011年第7期542-544,共3页 Chinese Journal of Tuberculosis and Respiratory Diseases
基金 河南省自然科学基金（82300450240）
关键词 中性粒细胞明胶酶相关脂质运载蛋白 核因子-ΚB 化疗患者 肺癌患者 非小细胞 预后 相关性 lipocalin
分类号 R734.2 [医药卫生—肿瘤]
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参考文献14

  • 1Kjeldsen L,Johnsen AH,Sengelov H,et al. Isolation and primary structure, of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem, 1993,268 : 10425-10432.
  • 2Trachtman H, Christen E, Cnaan A, et al. Urinary neutrophil gelatinase-associated lipocalcin in D + HUS: a novel marker of renal injury. Pediatr Nephru1,2006,21:989-994.
  • 3Sousa MM, Amaral JB, Guimaraes A, et al. Up-regulation of the extracellular matrix remodeling genes, biglycan, neutrophil gelatinase-associated lipocalin, and matrix metallopruteinase-9 in familial amyloid polyneuropathy. FASEB .I, 2005, 19: 124-126.
  • 4Kjeldsen L, Cowland JB, Borregaard N. Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat anti mouse. Biochim Biophys Aeta, 2000, 1482: 272-283.
  • 5Mishra J, Dent C, Tarabishi R, et al. Neutrophil gelatinase- associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet, 2005, 565 (9466) : 1251-1238.
  • 6Femandez CA, Yan L, Louis G, et al. The matrix metalloproteinase-9/neutrophil gelatinase -associat ed lipocalin complex plays a role in breast tumor growth and is present in the urine of breast cancer patients. Clin Cancer Res, 2005,11 : 5390- 5395.
  • 7Zhang H, Xu L, Xiao D, et al. Upregulation of neutrophil gelatinase-associated lipocalin in oesophageal squamous cell carcinoma: significant correlation with cell differentiation and tumour invasion. J Clin Pathol,2007 ,60 :555-561.
  • 8Friedl A, Stoesz SP, Buckley P, et al. Neutrophil gelatinase- associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression. Histoehem J, 1999, 31 : 433- 441.
  • 9Okamoto T, Sanda T, Asamitsu K. NF-kappa B signaling and carcinogenesis. Curt Pharm Des,2007,13:447-.462.
  • 10Yamanaka N, Sasaki N, Tasaki A, et al. Nuclear factor-kappaB p65 is a prognostic indicator in gastric carcinoma. Anticancer Res, 2004,24(2C) : 1071-1075.

同被引文献16

  • 1代岩,王起龙,王静,王焕勤,康燕,袁彦丽.中性粒细胞明胶酶相关蛋白及基质金属蛋白酶10在非小细胞肺癌中的表达及临床意义[J].中国实用医刊,2010,37(5):5-7. 被引量：2
  • 2Candido S, Maestro R, Polesel E, et al. Role of neutrophill gelatinase-associated lipocalin (NGAL) in human cancer[Jl. Oncotarget, 2014, 5(6): 1576- 1594.
  • 3Volpe V, Raia Z, Sanguigno L, et al. NGAL controls the metastatic potential of anaplastic thyroid carcinoma cells [J].Clin Endocrinol Metab, 2013, 98(1) : 228- 235.
  • 4Berger T, Cheung CC, Elia AJ, et al. Disruption of the lcn 2 gene in mice suppresses primary tumor formation but does not decrease lung metastasis[J]. Proc Natl Aead Sci USA, 2010, 107(7) : 2995-3000.
  • 5Kjeldsen L, Johnsen AH, Sengelcv H, et al. Isolation and primary structure of NGAL, a novel protein association witn human neutrophil gelatinase [J]. J Biol Chem, 1993, 268 (14) : 10425-10432.
  • 6Goetz DH, Holmes MA, Borregaard N, et al. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition [J]. Mol Cell, 2002, 10 (5): 1033-1043.
  • 7Kim BS, Yoon KH, Oh HM, et al. Involvement of p38 MAP kinase during iron chelator-mediated apoptotic cell death [J]. Cell Immunol, 2002, 220(2): 96-106.
  • 8Zang X, Zheng F, Hong H J, et al. Neutrophil gelatinase- associated lipocalin protects renal tubular epithelial cells in hypoxia-reperfusion by reducing apoptosis [J]. Int Urol Nephrol, 2014, 46(8): 1673-1679.
  • 9Liu MF, Jin T, Shen JH, et al. NGAL and NGALR are frequently overexpressed in human gliomas and are associated with clinical prognosis[J]. J Neurooncol, 2011, 104(1): 119-127.
  • 10Zhang H, Xu L, Xiao D, et al. Upregulation of neutrophil gelatinase-associated lipoealin in oesophageal squamous cell carcinoma: significant correlation with cell differentiation and tumour invasion [J]. J Clin Pathol, 2007, 60(5) : 555-561.

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中华结核和呼吸杂志
2011年 第7期

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