“缺氧后处理”对大鼠缺氧-复氧心室肌细胞的保护作用

“Hypoxic postconditioning” Protecting cardiac myocyte from hypoxia/reoxygenation injury in adult rats

采用模拟再灌的缺氧－复氧模型，在细胞水平直接观察到缺氧－复氧可致心肌细胞产生一氧化氮明显增加，并诱导心肌细胞凋亡；首次发现“缺氧后处理”可减轻心肌复氧损伤，明显提高心肌细胞存活率（Ｐ＜ ０．０５）。

Using adult rat cardiac myocyte hypoxia/recoxygenation model,we directly observed the marked elevated nitric oxide production of isolated cardiomyocytes induced by hypoxia/reoxygenation,with was accompanied by the increased myocyte apoptosis. The results of the present study demonstrate,for the first time,that “ hypoxic postconditioning” protect cardiac myocyte from reoxygen injury,and thus significantly increase cardiac myocyte viability.