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助力式超声弹性成像测定血栓组织高硬度区域面积在体外静脉模型血栓分期中的应用价值 被引量:3

Assisting stress ultrasound elastography with quantitative histography of distribution of stiffness for the age determination of venous thrombi: evaluation in an ex-vivo model of venous thrombosis
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摘要 目的 应用助力式弹性成像技术分析体外静脉血栓,了解不同血栓形成时间在弹性成像参数上的差别,评估超声弹性成像技术在静脉血栓分期中的应用价值.方法 利用静态助力式弹性成像技术对取自人大隐静脉的9根实验性血栓标本于1 d、3 d、6 d、9 d分别进行弹性成像数据分析;采用Metalab方法编制分析图像软件,定量分析血栓弹性图像上高硬度区域的分布面积,计算感兴趣区内高硬度区百分比(hard material percent,HM%).将HM%与声辐射力脉冲(acoustic radiation force impulse,ARFI)技术所获得的剪切波速度(SWV)进行相关分析.结果 使用助力式弹性成像技术观察到人大隐静脉血栓形成后1 d、3 d、6 d、9 d血栓HM%分别为(49.23±14.91)%、(68.75±10.03)%、(80.82±10.29)%及(91.98±4.10)%,HM%随着血栓形成时间的推移而逐渐增高,不同血栓HM%测值之间差异有统计学意义(P<0.05).HM%与ARFI技术测定的血栓内剪切波速度数据之间呈正相关关系(r=0.702,P=0.000).结论 使用助力式弹性成像技术计算HM%的方法在取自人的大隐静脉静脉血栓模型的血栓形成时间分期中有一定的应用价值,对今后弹性成像运用在人体静脉血栓分期中具有一定的参考作用. Objective To investigate the diagnostic value of assisting stress ultrasound elastographic quantitative parameter in determination of the thrombus age in an ex-vivo model of venous thrombi.MethodsAfter 1,3,6 and 9 days,9 saphenous vein samples with venous thrombosis were scanned by both tissue touch elasticity image and acoustic radiation force impulse (ARFI) respectively.For each group of thrombus age,a mean sheer strain was calculated in all thrombosis samples of the respective age.Furthermore,correlation of two sample data was analysed.Results The stiffness of thrombus age group of 1,3,6 and 9 days by tissue touch elasticity image were (49.23±14.91)%,(68.75±10.03)%,(80.82±10.29)% and (91.98±4.10)% respectively with significant differences among the parameters (P〈0.05).Quantitative data of thrombus age groups correlated positively by two kinds of these elasticity image significantly (r=0.702,P=0.000).Conclusions The assisting stress ultrasound elastographic method with HM% in this experiment setting of venous thrombosis is proved to be helpful in determination of the age of venous thrombi.The present results obtained in our experiment might provide a potential application in evaluation of deep vein thrombosis by the elastographic technology clinically.
出处 《中华超声影像学杂志》 CSCD 北大核心 2011年第7期583-586,共4页 Chinese Journal of Ultrasonography
关键词 超声检查 静脉血栓形成 弹性成像 Ultrasonography Venous thrombosis Elastography
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