STAT5和c-myc在大肠癌中的表达及意义

Expression of STAT5 and c-myc in Colorectal Carcinoma and Its Clinical Significance

目的探讨大肠癌中STAT5和c-myc蛋白表达与肿瘤病理特征的关系及两者的相关性。方法采用免疫组织化学SP法检测56例大肠癌组织STAT5和c-myc蛋白的表达,同时选取16例大肠腺瘤组织作对照。结果 STAT5在结肠癌组织中的阳性表达率(34/56,60.7%)明显高于大肠腺瘤组织(3/16,18.8%),P<0.01。STAT5表达与肿瘤Dukes临床分期及淋巴结转移均呈正相关(P<0.05)。c-myc在结肠癌组织中的阳性表达率(35/56,62.5%)明显高于大肠腺瘤组织(4/16,25.0%),P<0.01。c-myc表达与肿瘤分化程度、Dukes临床分期及淋巴结转移等均无明显相关(P>0.05)。STAT5和c-myc在大肠癌中表达呈正相关(r=0.359,P<0.01)。结论 STAT5和c-myc在大肠癌的发生发展中起重要作用;STAT5检测可作为判断大肠癌恶性程度的指标;大肠癌中c-myc表达可能受STAT5调控。

Objective To explore the expression of signal transducer and activator of transcription 5（STAT5） and c-myc in colorectal carcinoma（CRC） tissues and its correlation with clinicopathological features.Methods Protein levels of STAT5 and c-myc in CRC（56 cases） and colorectal adenoma（16 cases） tissues were detected by immunohistochemistry method.Results The positive rate of STAT5 in CRC（34/56,60.7%） was higher than that in colorectal adenoma（3/16,18.8%）,P0.01.STAT5 expression was related to Dukes stage and lymph node metastasis（P0.05）.The positive rate of c-myc in CRC（35/56,62.5%） was also higher than that in colorectal adenoma（4/16,25.0%）,P0.01.However,c-myc expression was not associated with differentiation degree,Dukes stage and lymph node metastasis（P0.05）.There was a positive correlation between the expression of STAT5 and c-myc in CRC（r=0.359,P0.01）.Conclusion STAT5 and c-myc play a role in the oncogenesis and development of CRC.STAT5 can be used to evaluate the biological behavior of CRC.The expression of c-myc is probably regulated by STAT5 in CRC.