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转录因子Foxp3与恶性肿瘤的研究进展 被引量：2

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摘要 0引言转录因子Foxp3（Forkhead box protein3,Foxp3）是forkhead/winged-helix转录因子家族中的一员。2001年Brunkow等[1]首次报道Foxp3。同年,Wildin和Bennett提出人类Foxp3基因与Scurfy小鼠Foxp3基因具有同源性。
作者 郭净 王菊勇 郑展 王青
机构地区 上海中医药大学附属龙华医院肿瘤研究所
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2011年第7期844-847,共4页 Cancer Research on Prevention and Treatment
基金 上海市科委创新行动计划资助项目(09140903600) 上海市教委项目(10YZ51)
关键词 FOXP3 肿瘤 研究进展
分类号 R730.3 [医药卫生—肿瘤]
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参考文献17

二级参考文献91

  • 1刘莉,丁乾,曹如波,王晶,姚军霞,黄士昂.恶性肿瘤患者外周血CD4^+ CD25^+调节T细胞的检测及其临床意义[J].临床肿瘤学杂志,2005,10(4):342-345. 被引量：16
  • 2张恒辉,费然,梅铭惠,廖维甲,王雪艳,丛旭,覃理灵,季颖,王松霞,魏来,陈红松.原发性肝细胞癌患者CD4^＋CD25^＋调节性T淋巴细胞的频率、表型及功能[J].中华肝脏病杂志,2007,15(4):266-272. 被引量：4
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共引文献39

同被引文献49

  • 1刘荣军,葛棣,丁建勇,熊思东,赵强,张镭,储以微.肺癌患者CD4^+ CD25^(high) Foxp3^+调节性T细胞的格局变化及意义[J].中国免疫学杂志,2006,22(6):531-534. 被引量：20
  • 2崔永生,李欣,于春雷,辛精卫,李一,付彤.肺癌和乳腺癌患者外周血中CD4^+CD25^+T细胞及foxp3 mRNA的变化特点及临床意义[J].吉林大学学报（医学版）,2006,32(5):843-846. 被引量：10
  • 3赵书山,李向培.FOXP3在免疫自稳中的决定性作用[J].中华风湿病学杂志,2006,10(10):620-623. 被引量：6
  • 4Hori S,Nomura T,Sakaguchi S.Control of regulatory T cell development by the transcription factor Foxp3[J] .Science,2003,299(5069):1057-1061.
  • 5Aarts-Riemens T,Emmelot ME,Verdonck LF,et al.Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T ceils from CD4(+)CD25(-) cells[J] .Eur J Immuno,2008,38(5):1381-1390.
  • 6Brunkow ME,Jefer EW,Hjerrild KA,et al.Disruption of a new fork-head/winged-helix protein,scurfin,results in the fatal lympho-proliferatived disorder of the scurfy mouse[J] .Nature Genet,2001,27(1):68-73.
  • 7Bassuny WM,Ihara K,Sasaki Y,et al.A functional polym orphism in the promote/ enhancer region of the FOXP3/Scurf in gene as sociated with type 1 diabetes[J] .Immun Ogenetics,2003,55:149-156.
  • 8Koh KP,Sundrud MS,Rao A.Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3[J] .PLos One,2009,4(12):e8109.
  • 9Sharma S,Yang SC,Zhu L,et al.Tumor cyclooxygen as e-2/prostaglan din E2-dependent promotion of Foxp3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer[J] .Cancer Res,2005,65 (12):5211-5220.
  • 10Fontenot JD,Gay in MA,Rudensky AY.Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells[J] .Nat Immuno,2003,4(4):330-336.

引证文献2

二级引证文献2

肿瘤防治研究
2011年 第7期

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