血清铁蛋白、血清铁与冠心病及其有关危险因素关系的临床研究

Clinical Research of the Relationship between Body Stored Iron and Coronary Heart Disease as well as it's Relative Risk Factors

目的：研究血清铁蛋白（ＳＦ）、血清铁（ＳＩ）与冠心病（ＣＨＤ） 之间的关系以及ＳＦ、ＳＩ与ＣＨＤ有关危险因素的相关关系。方法：测定４３ 例心肌梗塞（ＭＩ），４４ 例心绞痛（ＡＰ） 患者的ＳＦ、ＳＩ、血脂、血糖（ＢＧ）、血压、腰臀比（ＷＨＲ） 、体重指数（ＢＷＩ）水平，与４０ 例健康对照组进行分析。结果：ＡＰ组、ＭＩ组男、女、总体ＳＦ水平分别明显高于对照组（Ｐ＜ ０．０５～０．００１），但女性升高不如男性明显；ＳＦ水平与ＷＨＲ、甘油三脂（ＴＧ）、低密度脂蛋白（ＬＤＬ）呈正相关（ｒ＝ ０．４６，０．３４，０．４４），与高密度脂蛋白（ＨＤＬ）呈负相关（ｒ＝ － ０．３３）。结论：体内ＳＦ增加是ＡＰ、ＭＩ的主要易发因素之一；

Objective: Study the relationship among serum ferritin (SF), serum iron (SI), and coronary heart disease (CHD); study the correlation between body stored iron and risk factors of CHD. Method: We measured SF, SI, blood 1ipids,blood glucose,blood pressure, waist hip ratio (WHR) and body mass index in 43 patients with myocardial infarction (MI), in 44 patients with angina pectoris (AP) and 40 healthy subjects matching for age served as control. Results: SF levels were obviously higher in AP, in MI group than in control (P<0.05～0.001), but the increased levels were lower in female patients than in male ones. SF levels had positive correlation with WHR, serum triglyceride and low density lipoprotein cholesterol (r=0.46,0.34,0.44); negative correlation with HDL (r=-0.33). Conclusions: Accumulation of SF may be one of the strong risk factors of AP and MI. SF levels were affected by nutrient factors, especially some lipid metabolism and fat distribution of abdomen.