1Canalis E, Giustina A, Bilezikian JP. Mechanisms ofanabolic therapies for osteoporosis [J]. N Engl J Med, 2007,357(9):905-916.
2Baron R, Rawadi G. Wnt signaling and the regulation of bone mass[J]. Curt" Osteoporos Rep,2007,5(2):73-80.
3Balemans W, Ebeling M, Patel N, et al. Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)[J]. Hum Mol Genet,2001,10(5): 537-543.
4Balemans W, Patel N, Ebeling M, et al. Identification of a 52 kb deletion downstream of the SOST gene in pa- tients with van Buchem disease[J]. J Med Genet,2002,39 (2):91-97.
5Li X, Ominsky MS, Niu QT, et al. Targeted deletion of the sclerostin gene in mice results in increased bone for- mation and bone strength [J]. J Bone Miner Res,2008,23 (6):860-869.
6Winkler DG, Sutherland MK, Geoghegan JC, et al. Os- teocyte control of bone formation via sclerostin, a novel BMP antagonist[J]. EMBO J,2003,22(23):6267-6276.
7van Bezooijen RL, Svensson JP, Eefling D, et al. Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation [J]. J Bone Miner Res,2007,22(1): 19-28.
8Eddleston A, Marenzana M, Moore AR, et al. A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis [J]. J Bone Miner Res, 2009,24(10): 1662-1671.
9Ominsky MS, Vlasseros F, Jolette J, et al. Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength [J]. J Bone Miner Res,2010,25(5):9d8-959.
10Li X, Ominsky MS, Warmington KS, et al. Sclerostin an- tibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal os- teoporosis[J]. J Bone Miner Res,2009,24(4):578-588.
8Lelovas PP,Xanthos TT,Thoma SE,et al.The laboratory rat as an animal model for osteoporosis research[J].Comp Med,2008,58(5):424-430.
9Glass DA 2nd,Karsenty G.Molecular bases of the regulation of bone remodeling by the canonical Wnt signaling pathway[J].Current topics in developmental biology,2006,73:43-84.