中西医结合治疗慢性肾功能衰竭并心脏病变的疗效观察

Clinical observations on treatment with integrated traditional Chinese medicine and western medicine for chronic renal failure complicating cardiopathy

目的：探讨中西医结合治疗慢性肾功能衰竭（ＣＲＦ）并心脏病变的临床疗效。方法：将３５５ 例ＣＲＦ并心脏病变的患者随机分为中西医结合治疗组（治疗组，２９９ 例）和西医治疗对照组（对照组，５６ 例）。对照组给予血液透析合西药对症治疗，治疗组在对照组的一般治疗（２０１ 例血透，９８ 例结肠中药透析）基础上辨证分型加服中药汤剂治疗。观察治疗前后２ 组患者心脏病变和血肌酐（ＳＣｒ）的变化。结果：治疗组总有效率９３．９８％ ，对照组总有效率７５．００％ ，２ 组疗效比较有显著性差异（Ｐ＜ ０．０５）。２ 组治疗后ＳＣｒ均下降，治疗组治疗后〔（４５３．１±９２．２）μｍ ｏｌ／Ｌ〕与对照组治疗后〔（５９２．０±１１３．６）μｍ ｏｌ／Ｌ〕比较有显著性差异（Ｐ＜ ０．０５）。结论：中西医结合治疗ＣＲＦ并心脏病变优于单纯西医治疗。

Objective:To investigate the curative effects of integrated traditional Chinese Medicine (TCM) and western medicine(WM) on chronic renal failure (CRF) complicating cardiopathy.Methods:355 patients with CRF complicating cardiopathy were randomly divided into treated group ( n =299) which was treated with integrated TCM WM and control group ( n =56) which was treated with WM.The control group was treated with hemodialysis and symptomatic therapy using WM while in the treated group based on treatment with WM similar to control group (201 case with hemodialysis and 98 cases with colon dialysis) the TCM was added.Before and after therapy the cardiopathy and the changes in serum creatinine were observed.Results:In treated group the total effective rate was 93 98% but in control group it was 75 00%.In comparison between two groups the difference was significant ( P <0 05).After therapy in both groups the serum creatinine (SCr) was decreased but in treated group the decrease in SCr 〔(453 1±92 2)μmol/L after therapy〕 was much more significant than that in control group 〔(592 0±113 6)μmol/L after therapy, P <0 05〕.Conclusions:The treatment with integrated TCM WM for CRF complicating cardiopathy is superior to that with WM alone.