益生菌联合肠内营养对重度颅脑损伤病人的疗效观察

Observation on application of probiotics combined with enteral nutrition for severe brain trauma patients

目的:探讨益生菌联合含有可溶性膳食纤维的肠内营养(EN)制剂对预防重度颅脑损伤病人并发肺部感染、腹泻和营养不良的疗效。方法:选择重度颅脑损伤病人132例,分为试验组(采用益生菌联合含有可溶性膳食纤维的EN支持)和对照组(采用单纯EN支持),两组病人均由鼻胃管连续滴注EN液。并观察病人的菌群失调、肺部感染率和腹泻的发生率,比较两组病人营养支持前后血清清蛋白、血红蛋白和淋巴细胞计数等。结果:试验组病人菌群失调发生率、肺部感染率、腹泻率明显低于对照组(P<0.05),营养状况亦优于对照组(P<0.05)。结论:益生菌联合含有可溶性膳食纤维的EN制剂,能调整重度颅脑损伤病人的肠道菌群,降低肺部感染率和腹泻率,改善病人的营养状况。

Objective：To prevent pulmonary infection,diarrhea and malnourishment,probiotics combined with enteral nutrition solution enriched soluble dietary fiber was applied on severe brain trauma patients and the efficacy was observed.Methods：The 132 patients were randomly assigned into test group and control group.The former was supported by probiotics and soluble fiber nutritious solution,and the later was treated only with soluble fiber nutritious solution.Both groups were supported continuously by gravity feeding through nasal gastrol tube.Incidence of pulmonary infection and diarrhea was observed,and the serum albumin,hemoglobin,lymph-cell counts were measured before and after intervention.Results：Incidence of pulmonary infection and diarrhea of test group was lower than that of control group,and nutritional status of the test group was better than that of control group（P0.05）. Conclusion：For severe brain trauma patients,their intestinal flora can be modulated,and incidence of lung infection,diarrhea and malnutrition can be reduced by support of probiotics combined with soluble fiber nutritious solution.