阻塞性睡眠呼吸暂停综合征患儿体内生长激素水平的变化

Changes of growth hormone secretion in children with obstructive sleep apnea syndrome

目的探讨阻塞性睡眠呼吸暂停综合征(O SAS)对儿童体内生长激素(GH)分泌水平的影响。方法经患儿家长知情同意,选取南京市儿童医院经多导睡眠监测仪(PSG)确诊为O SAS的患儿45例为实验组,非O SAS患儿15例为对照组,应用酶联免疫吸附测定法(ELISA)测定晨起生长激素(GH)。结果 O SAS组患儿GH值为(8.96±1.74)ng/mL,明显低于对照组(10.09±1.54)ng/mL,差异有统计学意义。进一步分析显示轻中度O SAS组患儿体内的GH分泌水平与正常组差异无统计学意义,而重度O SAS体内的GH分泌水平与轻中度O SAS及对照组差异明显。进一步相关回归分析显示,GH的分泌量与O SAS患儿的氧减指数呈负相关(r=-0.507)。结论 O SAS患儿体内生长激素水平受到一定的抑制,尤其伴氧减指数增加的重度O SAS患儿下降明显,应早期治疗,以防影响患儿生长发育。

Objective To observe changes of growth hormone（GH） secretion levels in children with obstructive sleep apnea syndrome（OSAS）.Methods 60 in-patients in the Nanjing Children′s Hospital had polysomnography（PSG） performed.45 OSAS cases served as the experimental group,and 15 non-OSAS cases as the control group.Growth hormone secretion levels in both groups were examined by enzyme-linked immunosorbent assay（ELISA）.Results GH secretion level in the OSAS group was（8.96±1.74） ng/mL,significantly lower than that in the control group（10.09±1.54）ng/mL.And in the experimental group,there was no significant difference between mild and moderate cases,while they were obviously reduced in severe cases.Further correlation and regression analysis showed that GH secretion levels were negatively correlated with the oxygen de-saturation index（r=-0.507）.Conclusion Growth hormone secretion in OSAS patients was inhibited,especially in severe OSAS cases with a decrease of the oxygen de-saturation index.