突发聋和梅尼埃病鼓室灌注疗效与内耳MRI显影相关性

Relationship of trans-tympanic administration effect with inner ear MRI visualization in patients with Meniere′s disease and idiopathic sudden hearing loss

目的研究突发聋和梅尼埃病鼓室灌注疗效与内耳MRI显影的相关性。方法 17例患者(突发聋13例,梅尼埃病4例)给予鼓室插管并注射钆造影剂,术后1h、1d、6d行MRI连续扫描,1周后复查电测听,评估眩晕改善情况,分析钆剂是否透入内耳和症状改善的相关性。结果 17例中9例(突发聋5例,梅尼埃病4例)在插管注入钆剂后1h到6d的MRI检查中出现内耳高信号。另8例MRI未显影者听力没有进步。结论鼓室灌注造影剂能透入内耳者药物也能透入,治疗效果亦较好。

Objective To explore and analyze the relationship of transtympanic administration effect with inner ear MRI visualization in patients with Meniere′s disease and idiopathic sudden hearing loss.Methods 17 cases（13 cases of idiopathic sudden hearing loss and 4 cases of Meniere′s disease）were enrolled in the study.Gadolium,dexamethason or gentimycin were trans-tympanically injected,and all patients were scanned with MRI 1 h,1 d,and 6 d after operation.The relationship of the effect with MRI visualization was observed and analyzed.Results 9 cases（5 cases of idiopathic sudden hearing loss and 4 cases of Meniere′s disease） of the 17 had inner ear high signal 1h to 6d after gadolium was injected.The other 8 cases had neither signal in the inner ear nor improved hearing.Conclusion If transtympanically injected gadolium can permeate into the inner ear,dexamethoson and gentimycin would also permeate into it,and the therapy would have a good effect.