细胞骨架与神经退行性疾病

Cytoskeleton and neurodegenerative diseases

神经退行性疾病(Neurodegenerative disease)是一种以神经元退行性病变为基础的慢性进行性神经系统疾病,其病因十分复杂,其中线粒体功能障碍学说、氧化应激学说、蛋白质发生错误折叠聚集、炎症、免疫功能缺陷,基因突变等已经得到普遍认可。近年来的研究发现,细胞骨架在神经元变性过程中发挥了重要作用。细胞骨架是细胞质内蛋白质丝组成的纤维网架体系,其决定和维持着细胞的形态结构,同时参与细胞运动、分裂、胞浆运输等生命活动,对信号传导具有重要的意义。该文就其在神经退行性疾病方面的研究进行综述。

Neurodegenerative diseases is a kind of chronic progressive neurological disease characterized by neuron degeneration.There have been many theories accounting for this complex disease,including mitochondrial dysfunction,oxidative stress theory,misfolded protein aggregation,inflammation,immune defects,and genetic mutations.In recent years,researches have demonstrated that cytoskeleton played an important role in neuronal degeneration process.Cytoskeleton system determines and maintains cell morphology and it is involved in cell movement,division,cytoplasmic transport and of great significance to other signal transduction.In this review,we discuss recent research progress in neurodegenerative diseases.