溶血磷脂酸(LPA)对肿瘤转移的作用研究

Role of lysophosphatidic acid(LPA) in tumor metastasis

溶血磷脂酸(lysophosphatidic acid,LPA),是溶血磷脂(lysophospholopid,LP)的活性成分之一,是一种重要的细胞外信号递质和细胞内第二信使。在正常生理状态下,LPA具有促进细胞有丝分裂、影响细胞形态、加速伤口愈合等作用。近年来研究资料发现LPA与肿瘤发生及侵袭转移等恶性化程度密切相关,但只有少量资料在分子及基因水平探讨了LPA表达与肿瘤侵袭转移的关系,且基本还停留在实验室阶段,临床上尚未开发出靶向LPA的抗肿瘤转移的有效药物。该文以肿瘤转移的几大关键步骤为出发点,总结了LPA在肿瘤细胞增殖、血管生成、迁移等关键步骤中的作用机制,为临床上开发出作用于LPA相关靶点,抑制肿瘤转移的新药提供理论依据,为肿瘤临床及肿瘤研究工作者提供参考。

Lysophosphatidic acid（LPA）,a member of lysophospholopid（LP） family,is an important extracellular signal transmitter and intracellular second messenger.Under physiological conditions,LPA can promote mitosis,affect cellular morphology,and accelerate wound healing.Recently,clinical data have shown that LPA is closely associated with tumor progression including tumorigenicity,invasion and metastasis.However,the relationships between LPA expression and tumor metastasis at molecular level are poorly understood.Basically,current studies of this issue are positioned in preclinical stage and effective drugs targeting LPA against tumor metastasis are lacking in clinical settings.This review based on the key steps of tumor metastasis summarized the role and underlying mechanisms of LPA implicated in tumor cell proliferation,angiogenesis and migration in the hope of providing new approaches for LPA-targeted anti-tumor agent development and clinical management of tumors.