摘要
[目的] 探讨接触有机镓对动物骨镓、骨钙和骨磷含量的影响。[方法] 采用亚急性和慢性动物染毒实验,将不同剂量的有机镓灌胃,分别观察不同时间后大鼠的一般状况及处死后股骨中镓、钙、磷的含量及钙/磷比值。[结果] 亚急性染毒各剂量组动物股骨中镓及磷含量与对照组差别显著(P< 0.01),而骨钙值只有12m g/kg 剂量组与对照组有显著差异。慢性染毒各剂量组动物骨镓、钙、磷均与对照组差别显著(P< 0.05)。而实验组与对照组的骨中钙/磷比例却未见明显差异。给药期间动物未见明显体重影响及不良反应。[结论] 短期和长期接触有机镓均对大鼠骨镓及骨代谢有一定影响。
Objective] Study was conducted to explore the influence of an organogallium compound,2 dimethyl aminocyclohexoxy dimethyl gallium on the gallium,calcium and phosphorus level in rat bones.[Methods]The organogallium compound was given rats by gavage at different doses in subchronic and chronic experiments.The general status of rats was observed and interested elements in femurs were measured.[Results]In subchronic experiment,the bone gallium increased with increase of the dose,but the bone phosphorus decreased ( P <0.01),the bone calcium significantly increased only at a dose of 12 mg/kg.In chronic experiment,gallium,calcium and phosphorus levels were significantly different between treatment groups and control group( P <0 05),but not the ratio of calcium to phosphorus.There was no effect of treatment on growth and general status during experiments.[Conclusion]In subchronic and chronic experiments the certain effects of the organogallium compound tested on bone gallium level and metabolism of calcium and phosphorus were found.
关键词
有机镓
骨镓
骨钙
骨磷
organogallium
gavage in rats
bone gallium
bone calcium
bone phosphorus