摘要
［目的］ 探索有机镓化合物对视觉神经传导道路的功能影响。［方法］ 取白色家兔１２ 只，分１０、１５、２０ｍ ｇ／ｋｇ 三个致死量组，用２－二甲氨基环己氧基－二甲基镓（ＤＤＧ）一次性灌胃染毒，分别于染毒前、染毒后２４ｈ 及４８ｈ，对各组家兔测定视皮层诱发电位（ＶＥＰ）和视网膜电位（ＥＰＧ）。［结果］ １２只家兔中出现精神抑制症状严重的７ 只中毒家兔，均于染毒后２４ｈ 出现ＶＥＰ异常，表现为Ｂ波电位降低，Ｂ／Ａ比值减小。对其中４ 只家兔测定了ＥＲＧ，表现为ｂ 波电位降低，ｂ／ａ比值也减小。在存活动物中，随着中毒症状的恢复，上述二项指标均于４８～７２ｈ逐渐恢复至正常水平。［结论］ ＤＤＧ引起的视觉异常可能是视皮层功能抑制所致，是可逆的。
The visual evoked potential (VEP) and electroretinogram (ERG) were determined in rabbits to investigate the effects of 2 dimethyl aminocyclohexoxy dimethyl gallium (Naoyaojia),used as semi conductor raw material and an antimalarial agent,on nervous and visual function.The results showed that in the seriously intoxicated rabbits the amplitude of the B wave and the B/A ratio of VEP diminished,the amplitude of the b wave and b/a ratio of ERG diminished,too.In accompaning with recovering of toxic symptoms,the VEP and ERG parameters recovered to the normal level in the survived animals 48-72 hours after DDG gavage.
