急性冠状动脉综合征患者血清转化生长因子α和胰岛素生长因子2的变化及其临床意义

Expression of transforming growth factor α and insulin-like growth factor 2 in patients with acute coronary syndrome

目的探讨急性冠状动脉综合征患者血清转化生长因子α(TGF-α)和胰岛素生长因子(IGF-2)的变化及其临床意义。方法选择急性冠状动脉综合征患者(ACS组)21例,稳定型心绞痛患者(SAP组)24例,健康对照组22例。ACS患者入院即刻采血,其余研究对象第2天清晨空腹抽血,以放射免疫法测定TGF-α和IGF-2水平,同时检测心肌损伤标志物肌钙蛋白T(cTNT)。ACS组及SAP组均行冠状动脉造影检查。结果血清TGF-α水平ACS组、SAP组与正常对照组比较差异有统计学意义(P<0.05),在冠心病两亚组中,ACS组TGFα显著高于SAP组(P<0.05)。ACS组冠脉狭窄积分与血清TGF-α、IGF-2水平呈显著正相关(P<0.01),SAP组冠脉狭窄积分与TGF-α、IGF-2水平呈弱相关(P>0.05)。ACS组cTNT与血清TGF-α、IGF-2水平呈显著正相关(P<0.01),SAP组cTNT与血清TGF-α、IGF-2水平呈弱相关(P>0.05)。结论 TGF-α和IGF-2可能参与了急性冠脉综合征的基本病理过程。

Objective To study the expression of transforming growth factor-α（TGF-α）and insulin-like growth factor 2（IGF-2） in patients with acute coronary syndrome（ACS） and its clinical significance.Methods The serum level of TGF-α and IGF-2,cardiac marker troponin T were measured by radioimmunoassay in 21 patients with ACS and 24 patients with stable angina pectoris,with 22 healthy person as a control.for ACS patients,the blood sample was taken immediately at 2 hours after admission,and the others,the blood sample were taken in the morning the day after admission on empty stomach.All ACS and SAP groups were taken coronary angiography.Results The serum level of TGF-α displayed significant differences among group of ACS and group of SAP compared to normal controls（P0.05）.the serum level of TGF-α in ACS group was obviously higher than that in stable angina group（P0.05）.There existed a positive correlation between the level of TGF-α and IGF-2 with coronary stenosis scores in ACS group（P0.01）,but negative correlation in SAP group.it also showed that the level of TGF-α and IGF-2 had positive correlation with the level of cTNT in ACS group（P0.01） but negative correlation in SAP group（P0.05）.Conclusion TGF-α and IGF-2 might engage in the pathologic processes of acute coronary syndrome,and they could be used to evaluate the degree of coronary artery stenosis.