磷酸肌酸钠对小儿EB病毒感染后心肌的保护作用观察

The protective effects of creatine phosphate sodium on myocardium in children with infection of EB virus

目的观察磷酸肌酸钠对小儿EB病毒感染后心肌的保护作用。方法 80例EB病毒感染后心肌酶谱及肌钙蛋白T(CTnT)异常患儿,随机分为对照组(n=40)和治疗组(n=40)。对照组予常规抗病毒及对症支持治疗,治疗组在对照组基础上加用磷酸肌酸钠。观察及比较两组患儿治疗前后心肌酶谱及肌钙蛋白T(CTnT)的变化。结果治疗组患心肌酶谱及肌钙蛋白T较对照组有明显改善,两者相比较差异有统计学意义(P<0.05)。结论磷酸肌酸钠对小儿EB病毒感染后心肌的保护作用效果明显。

Objective To investigate the protective effects of creatine phosphate sodium on myocardium in children infected by EB virus.Methods 80 children who were infected by EB virus were randomly divided into treatment group（n=40）and control group（n=40）.They were all with the abnormality of myocardial enzyme and CTn-T.The treatment group was treated with creatine phosphate sodium,in addition to conventional antiviral treatment and symptomatic and supportive treatment given to the control group.The change of myocardial enzyme and CTn-T were observed and compared.Results Compared with the control group,the improve of myocardial enzyme and CTn-T of the treatment group were obvious.The differences of myocardial enzyme and CTn-T between two groups were statistically significant（P0.05）.Conclusion Creatine phosphate sodium have obvious protective effects on myocardium in children with infection of EB virus.