期刊文献+

颅脑损伤手术患者血糖增高对预后的影响及治疗(附462例报告) 被引量:2

下载PDF
导出
摘要 目的探讨颅脑损伤手术患者血糖增高对预后的影响及其治疗方法。方法回顾性分析462例颅脑损伤手术患者血糖增高的病例。入院6h内取肘静脉血测血糖值,血糖<9.4mmol/L者为A组(418例);血糖≥9.4mmol/L者为B组(44例)。动态监测空腹血糖,在治疗原发病基础上,采用降血糖对症处理,追踪观察预后情况。结果 A、B两组预后经方差分析,P<0.01,差异有统计学意义。入院时血糖越高,预后越差。术后血糖控制不良者,预后显著差于血糖控制良好者,重度颅脑损伤术后患者,血糖值明显高于正常值。结论血糖越高,伤情越重,病死率越高,血糖值超过12mmol/L为预后不良的一个客观指标,及时有效的控制血糖能提高救治效果。
出处 《四川医学》 CAS 2011年第7期1115-1116,共2页 Sichuan Medical Journal
  • 相关文献

参考文献6

二级参考文献19

  • 1刘兴洲,郭玉璞.高血糖与急性脑卒中[J].中华神经精神科杂志,1995,28(5):285-287. 被引量:50
  • 2[1]Miller JD Minor, moderate and severe head injury. NeurosurgRev, 1998,9:135~136.
  • 3[2]Andersom SL, Housley AM. Glasgow outcome scale: An interratter relabitity study. Brain Inury, 1993,7: 309~311.
  • 4Kushner M, Nencini P, Reivich M, et al . Relation hyperglucemia early in ischemic brain infarction to cerebral anatomy, metabolism and clinical outcome[ J]. Ann Neurol, 1990,28( 1 ) : 129.
  • 5Tyson RL, Sutherland GR, Peeling J, et al .23 Nuclear magnetic resonance spectral change during and after forebrain ischemia in hypogtycemic, normoglycemic, and hyperglyeemic rats[ J]. Strioke, 1996,27(1):957.
  • 6Van den Berghe G, Wouters P, Weekets F, et al . Intensive insulin therapy in critically ill patients[J] .N Engl J Med,2001,345(19) : 1359- 1367.
  • 7Kuroda M, Honnor RC, Cushman SW, et al . Regulation of insulinstimulated glucose transport in the isolated rat adipocyte.cAMPindependent effects of lipolytic and antilipolytic agents[J]. J Bid Chem,1987.262:215.
  • 8Strommer L,Permert J,Amelo U, et al .Skeletal muscle insulin resistance after trauma: insulin signaling and glucose transport[J] .Am J Physiol,1998,275: E351.
  • 9Miura A, Ishizuka T, Kanoh Y, et al.Effect of tumor necrosis factoralpha on insulin signal transduetion in rat adipocytes: relation to PKC beta and zeta translocation[J]. Bioxchem Acta, 1999,1449:227.
  • 10Khanna S, Boy S, Packer L, et al. Cytokine - induced gtucose uptake in skeletal muscle:redox regulation and the role of alpha- lipoic acid[J]. Am J Physiol, 1999,276(5 pt2) : R1327.

共引文献20

同被引文献32

  • 1Donatelli F,Cavagna P,Di Dedda G,et al.Correlation betweenpre-operative metabolic syndrome and persistent blood glucose ele-vation during cardiac surgery in non-diabetic patients[J].J ActaAnaesthesiol Scand,2008,52(8):1103-1110.
  • 2Van den Berghe G.How does blood glucose control with insulinsave lives in intensive care[J].J Clin Invest,2004,114(9):1187-1195.
  • 3Voisine P,Ruel M,Khan TA,et al.Diferences in gene expressionprofiles of diabetic and nondiabetic patients undergoingcardiopul-monary bypass and cardioplegic arrest[J].J Circulation,2004,110(11 Suppl 1):Ⅱ280-Ⅱ286.
  • 4Najmaii S,Redford D,Larson DF.Hyperglycemia as an effect ofcardiopulmonary bypass:intra-operative glucose management[J].JExtra Corpor Technol,2006,38(2):168-173.
  • 5Verma S,Maitland A,Weisel RD,et al.Hyperglycemia exaggeratesischemia repefusion-induced cardiomyocyte injury:reversal withendot helinantagonism[J].J Thorac Cardiovasc Surg,2002,123(6):1120-1124.
  • 6Ascione R,Rogers CA,Rajakaruna C,et al.Inadequate blood glu-cose control is associated with in-hospital mortality and morbidityin diabetic and nondiabetic patients undergoing cardiac surgery[J].J Circulation,2008,118(2):113-123.
  • 7Doenst T,Wijeysundera D,Karkouti K,et al.Hyperglycemia duringcardiopulmonary bypass is an independent risk factor for mortalityin patients undergoing cardiac surgery[J].J Thorac CardiovaseSurg,2005,130(4):1144.
  • 8Conroy BP,Grafe MR,Jenkins LW,et al.Histopathologic conse-quences of hyperglycemic cerebral ischemia during hypothermiceardiopulmonray bypass in pigs[J].J Ann Thorac Surg,2011,71(4):1325-1334.
  • 9Turina M,Fry DE,Polk HC Jr.Acute hyperglycemia and the innateimmune system:clinical,cellular,and molecular aspects[J].J CritCare Med,2005,33(7):1624-1633.
  • 10Smith CE,Styn NR,Kalhan S,et al.Intraoperative glucose controlin diabetic and nondiabetic patients during cardiac surgery[J].JCardiothorac Vasc Anesth,2005,19(2):201-208.

引证文献2

二级引证文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部