布洛芬凝胶中薄荷脑的气相色谱测定

GC DETERMINATION OF MENTHOL IN IBUPROFEN GEL

采用ＦＩＤ气相色谱仪，Ｂｐ ２０ 毛细管柱（２５ ｍ ×３．２ ｍ ｍ ，膜厚１．０ μｍ ），二阶程序升温分离布洛芬凝胶中的薄荷脑，基质不干扰测定，以正辛醇为内标。线性范围在２２０～６００ μｇ／ｍ ｌ。平均回收率９９．５％ ，ＲＳＤ ０．５％ 。

A programmed temperature gas chromatography for the determination of menthol in ibuprofen gel was developed, using FID detector, Bp 20 column and n octyl alcohol as internal standard. The result showed a good linear relationship in concentration range of 200~600 μg/ml ( r =0.9998). The average recovery was 99.5%, the RSD was 0.5%.