胺碘酮对预防预激综合征射频消融术中心房颤动发生的研究

EFFECTS OF AMIDARONE ON RADIOFREQUENCY CATHETER ABLATION IN THE WOLLF PARKINSONG WHITE SYNDROME PATIENTS WITH ATRIAL FIBRILLATION

研究小剂量胺碘酮对预激综合征（ＷＰＷ）射频消融术中心房颤动（ＡＦ）发生的预防作用。１２例ＷＰＷ 合并ＡＦ患者，男７ 例，女５ 例，２４～６４ 岁，平均（４１±１５）岁。１０ 例体表心电图提示显性预激，２ 例提示隐匿性预激。所有患者均有ＡＦ发作病史和心电图。射频消融按常规方法进行，术前服用胺碘酮３～４ 周，０．２ｇ／ｄ。１２ 例患者全部射频消融成功，２ 例术中发生ＡＦ，数分钟后自行转为窦性心律。结果表明，射频消融是治疗ＷＰＷ 合并ＡＦ的有效方法，小剂量胺碘酮可减少和避免术中ＡＦ发作，并且不阻断旁路的前传和逆传。

To evaluate antifibrillation effect of low dose amidarone during radiofrequency Catheter Ablation(RFCA) in the Wollf Parkinsong White syndrome(WPW) patients with atrial fibrillation(AF), electrophysiologic studies and RFCA were performed in 12 patients with WPW and AF(10 with anterograde conduction of accessory pathway and 2 with concealed accessory pathway). Episodes of AF were documented by suffice ECG. Amidarone(0.2g/d) was given in all patients for 3~4 weeks. RFCA were successful in all 12 patients. During follow up only 1 of these had recurrent AF.2/12 patients had episodes of unsustained AF. The results indicated that RFCA of the accessory pathway markedly reduce the recurrence of AF in patients with WPW. The low dose amidarone is effective in preventing episodes of AF during RFCA and increase the success rate in WPW patients with AF.