自制SDMC-2液对人右心房肌小梁低温延时保存后收缩功能的实验研究

EFFECT OF SDMC 2 SOLUTION ON THE RECOVERY OF HUMAN RIGHT ATRIAL TRABECULAE CONTRACTING FROM LONG TERM HYPOTHERMIC STORAGE

为提高离体心脏保存效果，简化心脏保存方式，将人右心房肌小梁，保存在ＳＤＭＣ－２ 液中，０℃保存８ｈ 后，放入常温（３７℃）并通入９５％ Ｏ２＋ ５％ ＣＯ２ 混合气体的ＫＨ 液中，测量肌小梁的收缩强度。结果表明：ＳＤＭＣ－２ 液保存组肌小梁收缩强度明显优于对照组（Ｐ＜ ０．００１），于３０ｍ ｉｎ 观察期间无下降。ＳＤＭＣ－２ 液低温长时间保存人右心房肌小梁，效果好。

To enhance isolated heart preservation effect and simplify heart preservation method, SDMC 2 solution(Shandong Medical University Cardiosol 2) was prepared according to the authors recipe. After a 8 hours preservation period at 0℃, human right atrial trabeculae were immersed in a KH solution maintained at 37℃ and aerated with 95%O 2+5%CO 2 restimulated and then recovery of function was monitored for 30 minutes. The results showed that SDMC 2 solution provided the best recovery of developed force of trial myocardium (P<0.001) which had not been decreasing for 30 minutes. SDMC 2 solution has the best preservation effect of the tested solutions.