原发性高血压患者血浆肾上腺髓质素、内皮素-1的改变

Changes of Plasma Adrenomedullin and Endothelin-1 in Essential Hypertension Patients

目的 :观察高血压患者血浆肾上腺髓质素 (ADM)和内皮素 - 1(ET- 1)的改变。 方法 :用特异性的放射免疫法测定 5 2例原发性高血压患者 [其中高血压 期 (高血压 期组 ) 2 5例 , 期 (高血压 期组 ) 16例 , 期 (高血压 期组 ) 11例 ]血浆 ADM、ET- 1水平并与正常对照组相比较。 结果 :高血压 期组血浆 ADM、ET- 1水平显著高于高血压 期组、高血压 期组 (P<0 .0 1) ,高血压 期组、高血压 期组两者水平高于正常对照组 (P<0 .0 1) ,而高血压 期组与高血压 期组之间没有显著差异。 结论 :高血压时血管细胞为抵消或减轻 ET- 1等缩血管物质的过度分泌而代偿性的合成和分泌 ADM增多。

Objective:To assess the changes of plasma adrenomedullin(ADM)and endothelin 1(ET 1)in essential hypertensive patients. Methods:Specific radioimmunoassay was used to measure the plasma concentrations of ADM and ET 1 of 52 patients with essential hypertension among whom 25 patients were at stageⅠ,16 stageⅡand 11 stageⅢ. Results:The plasma concentrations of ADM and ET 1 of hypertension(including all 3 stage)are significantly higher than that of control.The plasma concentrations of ADM and ET 1 in severe hypertensive patients(stage Ⅲ)are significantly higher than that of in mild and moderate(stageⅠand stageⅡ)patients,but there is no statistically significant difference between the patients of stage Ⅱand stageⅠ. Conclusion:During the course of hypertension,vascular cell synthesize and secrete more ADM to compensate for the excessive secretion of ET 1.