389例非淋菌性尿道炎支原体感染状况及药敏结果分析

Infection and Drug Susceptibility Analysis of Mycoplasma in 389 Patients with Nongoncoccal Urethritis

目的通过对389例非淋菌性尿道炎分泌物进行支原体培养和药敏检测,了解解脲支原体（Uu）和人型支原体（Mh）的感染情况及其对抗生素的药敏性,以指导临床合理用药。方法采用珠海生物工程有限公司支原体试剂盒进行支原体培养鉴定及药敏检测。结果 389例非淋菌性尿道炎标本中,阳性标本90例,占23.1%。20-40岁年龄段阳性率明显高于41-60岁年龄段阳性率,差异有统计学意义（P〈0.05）。Uu感染率女性明显高于男性。药敏结果显示支原体对强力霉素、克拉霉素、交沙霉素、四环素比较敏感;对氧氟沙星、红霉素、乙酰螺旋霉素耐药率高。结论支原体感染Uu感染率最高,临床首选药物应为强力霉素、克拉霉素、交沙霉素,以便指导临床选择用药。

Objective To investigate infections and drug susceptibility of Ureaplasma urealyticum（Uu） and Mycoplasma hominis（Mh） in 389 patients with nongoncoccal urethritis,and to guide the rational use of antibiotics in clinical practice.Methods Mycoplasma culture and drug susceptibility test were carried out using mycoplasma detection kit produced by Zhuhai Bioengineering Technology Limited Company.Results Among the specimens collected from nongoncoccal urethritis patients,the positive specimens counuted for 23.1%（90/389）.The positive rate of mycoplasma in age group of 20~40 years was significantly higher than that in age group of 41~60 years,and the difference was statistically significant（P0.05）.The infection rate of Ureaplasma urealyticum in female was significantly higher than that in male.Drug susceptibility test showed that mycoplasma was sensitive to doxycycline,clarithromycin,josamycin,and tetracycline,moreover,mycoplasma was highly resistant to ofloxacin,erythromycin and acetylspiramycin.Conclusions Among mycoplasma infections,the infection rate of Ureaplasma urealyticum was higher.Doxycycline,clarithromycin,and josamycin should be the first choice for treating Ureaplasma urealyticum or Mycoplasma hominis infection.