p53基因在幽门螺杆菌致胃癌机制中的作用

The Role of p53 Gene in H.pylori Related Gastric Cancer

为了探讨Ｈｐ 感染在胃癌及癌前病变中的作用机制，应用分子生物学方法检测胃粘膜标本中ｐ５３ 基因点突变情况。结果显示， Ｈｐ 阳性患者ｐ５３ 基因的突变发生率明显高于Ｈｐ 阴性者；胃癌组Ｈｐ 阳性患者中ｐ５３ 的突变率显著高于阴性者。结果表明，Ｈｐ 的感染可能与胃癌的发生有关，基因突变可能是Ｈｐ 致胃癌的作用机制之一。

To determine the role of Helicobacter pylori(Hp) in the development of gastric cancer and gastric precancerous lesions,the point mutation of p53 gene was detected by polymerase chain reaction single strand conformation polymorphism analysis direct sequence(PCR SSCP Sequence).The results showed that the mutational rates of p53 gene in Hp positive patients were significantly higher than those in Hp negative patients.For gastric cancer patients,the mutational rate of p53 gene in Hp positive patients were significantly higher compared with Hp negative patients.The result indicated that Hp infection may be in relation with gastrocarcinogenesis,the gene mutation may play a role in Hp related gastric cancer.