罗汉果甜苷的生物活性研究

Studies on the Pharmacological Profile of Mogrosides

报道了罗汉果 Ｓｉｒａｉｔｉａ ｇｒｏｓｖｅｎｏｒｉｉ（Ｓｗｉｎｇｌｅ） Ｃ． Ｊｅｆｆｅｒｙ ｅｘ Ｌｕ ｅｔ Ｚ． Ｙ． Ｚｈａｎｇ提取物罗汉果甜苷（ｍｏｇｒｏｓｉｄｅｓ，Ｍｏｇ）的祛痰、镇咳、平喘等药理作用。结果表明：Ｍｏｇ能增加小鼠气管酚红的分泌量，抑制氨水诱发的小鼠咳嗽，促进青蛙食道粘液移动，但并不影响枸橼酸诱发的豚鼠哮喘。提示Ｍｏｇ有化痰镇咳作用，是罗汉果的有效活性成分。

The expectorant, antitussive and anti-asthmatic effects of mogrosides (Mog), extracted from traditional Chinese medicine Luohanguo [Siraitia grosvenorii (Swingle) C. Jeffery ex Lu et Z. Y. Zhang], was studied. Results of the study showed that Mog increased the secretion of PSP from mice bronchi, prompted the ciliary movement of frog esophagus and relieved cough caused by the irritation of ammonia water in mice. but did not alleviate the asthma induced by citric acid in mice. These data verified the truth of thousands years of Chinese medical practice in the use of the herb, and proved that MOG is the active composition of Luohanguo.