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病毒性肝炎慢性化研究近况 被引量:1

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摘要 The chronicity of viral hepatitis is a very complex problem.The mechanism of chronicity has been studied.These investigations were related to a lot of fields.For sample molecular virology, immunology, genetic and so on. The results suggested that it was associated with defective function of immunology,low expression of HLA-1,depressed function of PBMC, deficiency T/B cell,imbalance of regulation between cytokines,autoimmune phenomena Viral mutation also was an important factor .The clue for prevention and treatment of viral hepatitis would be provided by the further study on chronicity of viral hepatitis. The chronicity of viral hepatitis is a very complex problem.The mechanism of chronicity has been studied.These investigations were related to a lot of fields.For sample molecular virology, immunology, genetic and so on. The results suggested that it was associated with defective function of immunology,low expression of HLA-1,depressed function of PBMC, deficiency T/B cell,imbalance of regulation between cytokines,autoimmune phenomena Viral mutation also was an important factor .The clue for prevention and treatment of viral hepatitis would be provided by the further study on chronicity of viral hepatitis.
机构地区 解放军
出处 《基础医学与临床》 CSCD 1999年第6期8-12,共5页 Basic and Clinical Medicine
关键词 病毒性肝炎 慢性化 viral hepatitis chronicity hepatitis B virus(HBV) hepatitis C virus(HCV)
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参考文献4

  • 1Chen M,Gastroenterology,1999年,116卷,135页
  • 2Tsai S L,Gastroenterology,1998年,115卷,4期,954页
  • 3Tsai T,Hepatology,1997年,25卷,2期,449页
  • 4Agnello V,IX Triennial Int Sympo Viralhepattis and Liverdis,1996年,B122页

同被引文献9

  • 1张文军,李月琴,李泓剑,贾雪芳,张欣,周天鸿.Bridge Sequence对M1GS核酶体外切割活性的影响[J].广东药学院学报,2006,22(5):537-540. 被引量:5
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  • 6Zhang WJ, Li ILl, Li Y Q, et al. Construction of an effective M1GS ribozyme targeting HCMV UL97 mRNA segment in vitro [ J ]. Acta Genetica Sinica, 2005, 32 : 1205 - 1212.
  • 7Walker SC, Engelke DR. Ribonuclease P: The evolution of an ancient RNA enzyme [J]. Crit Rev Biochem Mol Biol, 2006, 41 : 77 - 102.
  • 8Gomez J, Martell M, Quer J, et al. Hepatitis C viral quasispecies [J]. J Viral Hepat,1999,6:3 -16.
  • 9陈慧毅,卢捷,李瑞,辛中帅,阴彬,龚燕华,彭小忠.支持HCV 1b亚基因组复制的细胞模型的建立[J].基础医学与临床,2009,29(6):570-574. 被引量:1

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