精神分裂症患者脑脊液LPO、SOD、TRP及5-HT的变化

Observation on Lipid Peroxide,Superoxide Dismutase, Tryptophan and Serotonin in CSF with Schizophrenics

目的 了解精神分裂症患者脑脊液中脂质过氧化物（ＬＰＯ）、超氧化物歧化酶（ＳＯＤ）、色氨酸（ＴＲＰ）及五羟色胺（５－ＨＴ）的变化。 方法 测试１０２例精神分裂症患者及３２例健康人（对照组）脑脊液中ＬＰＯ、ＳＯＤ、ＴＲＰ及５－ＨＴ，并以Ａｎｄｒｅａｓｅｎ 分型标准划分为Ⅰ型精神分裂症（６８ 例）和Ⅱ型精神分裂症（３４例）。 结果 精神分裂症患者脑脊液中ＬＰＯ明显高于对照组（Ｐ＜ ０．０１），ＴＲＰ明显低于对照组（Ｐ＜ ０．０１）；Ⅰ型精神分裂症患者比Ⅱ型患者脑脊液中ＬＰＯ与ＳＯＤ明显高（Ｐ＜０．０１）、ＴＲＰ与５－ＨＴ明显低（Ｐ＜ ０．０１）。 结论 精神分裂症患者脑脊液中５－ＨＴ 前体ＴＲＰ低于对照组，Ⅰ型患者ＴＲＰ与５－ＨＴ功能明显低于Ⅱ型患者，可能与自由基代谢紊乱和自由基酶防御系统异常而引起的脂质过氧化损害有关。

To observate on the levels of lipid peroxide(LPO),superoxide dismutase(SOD),tryptophan(TRP) and serotonin(5 HT) in cerebral spinal fluid(CSF) with schizophrenics \ Methods\ We determined the levels of LPO,SOD,TRP and 5 HT in CSF of 102 patients with schizophrenics and 32 healthy voluteer controls The patients were divided into positive type(type Ⅰ) and negative type(type Ⅱ) by Andreasen's definition \ Results\ It was shown that there were not any differences in levels of SOD and 5 HT in CSF between schizophrenics and controls,but the level of LPO in CSF of schizophrenics was significantly higher than that of controls and the level of TRP in CSF of schizophrenics was significantly lower than that of controls \ Conclution\ It was also found that the levels of LPO,SOD,TRP and 5 HT were significantly difference between positive and negative type patients \;