高纯度尿促性腺激素对IVF-ET妊娠结局的影响

The influence of highly purified HMG on pregnancy outcome in vitro fertilization

目的:探讨体外受精-胚胎移植(IVF-ET)超促排卵周期中应用高纯度尿促性腺激素(HP-HMG,贺美奇)对妊娠结局的影响。方法:回顾性分析117个IVF-ET周期,根据超促排卵周期中是否使用HP-HMG将其分为两组,A组(n=63)应用果纳芬(r-FSH,重组卵泡刺激素),B组(n=54)加用贺美奇,比较两组妊娠率、流产率、着床率、持续妊娠率和持续着床率。结果:两组鲜胚移植周期妊娠率、流产率、着床率、持续妊娠率和持续着床率比较差异有统计学意义(P<0.05);两组冻胚移植周期妊娠率和着床率比较差异无统计学意义(P>0.05),而流产率、持续妊娠率和持续着床率比较差异有统计学意义(P<0.05)。结论:长方案超促排卵适时加用HP-HMG可以改善胚胎质量和子宫内膜容受性,提高持续妊娠率和持续着床率,降低流产率。

Objective：To study the influence of highly purified HMG on pregnancy outcome in vitro fertilization.Methods：117 patients（retrospective study）underwent IVF-ET cycles were divided into two groups.The patients of group A（n=63） were stimulated with r-FSH,the patients of group B（n=52） were stimulated with r-FSH and HP-HMG.The contrast pregnancy rate,miscarriage rate,implantation rate,ongoing pregnancy rate and ongoing implantation rate between group A and group B were compared.Results：There were statistical significant differences（P0.05） between group A and group B in pregnancy rate,miscarriage rate,implantation rate,ongoing pregnancy rate and ongoing implantation rate in fresh embryo transfer cycles,and there were no statistical differences（P0.05） in pregnancy rate and implantation rate while statistical significant differences（P0.05） in miscarriage rate,ongoing pregnancy rate and ongoing implantation rate in frozen embryo transfer cycles.Conclusion：To supplement HP-HMG to r-FSH in COH（controlled ovarian hyperstimulation） is useful to improve quality of embryos and inner membrance receptivity,and increases ongoing pregnancy rate and ongoing implantation rate and decreases miscarriage rate.