摘要
目的 观察三种停搏液的保护心肌效果,并对其效应进行对比研究。 方法 应用改良的Langendorff离体大鼠心脏灌注装置,分别灌注三种冷停搏液:StThom asⅡ号停搏液(I组)、STⅡ号+ 维拉帕米1 m g/L(Ⅱ组),STⅡ号+ 美托洛尔0.1 m g/L(Ⅲ组),比较三组心肌保护效果。 结果 Ⅱ组、Ⅲ组心肌缺血再灌注后心肌含水率、心肌酶改变及超微结构损伤明显轻于Ⅰ组,冠脉流量恢复率明显高于Ⅰ组。 结论 维拉帕米、美托洛尔对心肌缺血再灌注有一定的保护作用。
To observe effect of three sorts of cardioplegia for protecting myocardial and comparison with each other \ Methods\ By using the modified Langendorff device for isolated rat heart \ Three sorts of cardioplegia including ST cardioplegia(STⅡ),verapamil(1 mg/L) or metoprolol(0 1 mg/L) adding to STⅡ respectively were perfused into rat hearts and myocardial protection effects were studied \ Results\ The water content, changes of enzymes and injury of micro structure of myocardial in the verapamil or metoprolol group was significantly less than that of potassium and recovery of coronary vessels flow were improved more than that of the later significantly \ Conclusion\ Verapamil or metoprolol play a better role in protecting myocardium after I/R \;
出处
《福建医科大学学报》
1999年第4期428-431,共4页
Journal of Fujian Medical University
关键词
维拉帕米
美托洛尔
心肌保护
verapamil
metoprolol
myocardial protection
rat