肝康膏对四氯化碳所致小鼠急性肝损伤的保护作用

Protective effects of the Gankang paste on acute liver injury induced by carbon tetrachloride in mice

[目的]研究肝康膏对四氯化碳所致小鼠急性肝损伤的保护作用.[方法]用四氯化碳建立小鼠急性肝损伤模型,肝康膏大、中、小剂量组小鼠灌胃给予2.00,1.00,0.50g/kg肝康膏提取物,用比色分析法测定血清丙氨酸氨基转移酶(ALT)活性及肝组织超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性和丙二醛(MDA)含量.[结果]肝康膏大、中、小剂量组血清ALT活性和肝组织MDA含量与模型对照组比较显著降低(P<0.01),肝组织SOD和GSH-Px活性明显升高(P<0.01,P<0.05).[结论]肝康膏对四氯化碳所致小鼠急性肝损伤具有一定的保护作用.

OBJECTIVE To study the protective effects of Gankang paste on acute liver injury induced by carbon tetrachloride（CCl4） in mice.METHODS The acute hepatic injury models in mice were established by the subcutaneous injection with the CCl4,and 2.00,1.00,0.50 g/kg of the Gankang paste extract were intragastrically administrated,and the activity of ALT in serum,content of MDA and activities of SOD and GSH-Px in liver were detected by colorimetric method.RESULTS As compared with the model control group,the activity of ALT in serum was significantly increased（P0.01）,and the content of MDA in liver were significantly decreased（P0.01） in large,middle and small dosages of the Gankang paste groups,and the activities of SOD and GSH-Px in liver were significantly increased（P0.01,P0.05）.CONCLUSION The Gankang paste has protective effects for acute liver injury induced by CCl4 in mice.