一种复方季铵盐类消毒液杀灭嗜肺军团菌效果的研究

STUDY ON BACTERICIDAL EFFICACY OF A QUATERNARY AMMONIUM COMPOUNDS DISINFECTANT TO LEGIONELLA PNEUMOPHILA

目的研究一种复方季铵盐消毒剂对嗜肺军团菌杀灭效果及其影响因素。方法应用悬液定量杀菌试验方法,对以二癸基二甲基氯化铵为杀菌成分的复方季铵盐消毒液杀灭嗜肺军团菌的效果及其影响因素进行了观察。结果以活性物含量为59.2 mg/L的该复方季铵盐消毒剂对悬液内嗜肺军团菌作用5 min,平均杀灭对数值>5.0。该复方季铵盐消毒剂随浓度增加和作用时间延长,其杀菌作用增强;但其随消毒液pH值降低,杀菌作用减弱。结论该复方季铵盐消毒剂在较低浓度下对嗜肺军团杆菌杀灭效果较好,但消毒液pH值偏酸性会降低其杀菌效果。

Objective To study the bactericidal efficacy and influencing factors of a quaternary ammonium compounds disinfectant to Legionella pneumophila.Methods Suspension quantitative bactericidal test was performed to observe the germicidal efficacy to L.pneumophila of didecyldimethylammonium chloride compounds disinfectant and the influencing factors.Results The killing log value of L.pneumophila was above 5.0 when the quaternary ammonium compounds disinfectant containing 59.2 mg/L active ingredient contact with 5 minutes.The bactericidal efficacy was enhanced with increasing disinfectant concentration and prolonging contact time.The bactericidal efficacy was decreased with the down of pH.Conclusion The quaternary ammonium compounds disinfectant can kill L.pneumophila at low concentration,but acidic pH can decrease its germicidal efficacy.