摘要
目的:观察给SD大鼠摄入蔗糖甜味觉溶液后对弓状核内NPY及FOS表达的影响。方法:给实验组SD大鼠摄入15ml蔗糖溶液,给对照组SD大鼠摄入15ml蒸馏水,2h后应用免疫组织化学方法观察弓状核内NPY及FOS表达。应用统计软件分析实验组与对照组NPY及FOS表达情况的差异性。结果:与对照组相比,给大鼠蔗糖甜味觉溶液后引起弓状核NPY及FOS表达的显著增多。结论:甜味觉食物的促食欲作用可能与其激活了弓状核内的NPY能神经元,使NPY表达上调有关。
Objective： To investigate the effect of sweet taste stimulation on neuropeptide Y and Fos expression in the arcuate nucleus of the rats.Methods： The experimental group rats intook sucrose solution 15mL,and the control group rats intook distilled water 15mL,2 hours later,the expression of neuropeptide Y and Fos in the arcuate nucleus was detected by immunohistochemistry.Using statistical software to analyze the difference of neuropeptide Y and Fos expression in the arcuate nucleus between the experimental group and the control group.Results： Compared with the control group,neuropeptide Y and Fos expression in the arcuate nucleus in the experimental group rats significantly increased.Conclusion： Appetite-promoting effect of the sweet taste food may be related to activation of the arcuate nucleus NPY neurons and up-regulation of NPY.
出处
《陕西医学杂志》
CAS
2011年第7期778-781,共4页
Shaanxi Medical Journal
基金
陕西省卫生厅科研基金资助项目(2010D57)
西安医学院校级课题(2007QN05)
