急性冠状动脉综合征患者血清单核细胞趋化蛋白-1和干细胞因子的变化

Changes of serum levels of MCP-1 and SCF in patients with acute coronary syndromes

目的:检测急性冠状动脉综合征(ACS)患者血清单核细胞趋化蛋白-1(MCP-1)和干细胞因子(SCF)的变化,探讨MCP-1和SCF与ACS的关系。方法:纳入急性心肌梗死患者41例,不稳定型心绞痛患者45例,对照组32例,应用ELISA法测定其血清MCP-1和SCF的水平。结果:心肌梗死组和心绞痛组MCP-1水平均明显高于对照组(P<0.01和P<0.05)。心肌梗死组及心绞痛组SCF水平略高于对照组,但差异无统计学意义。心肌梗死组MCP-1及SCF水平与血白细胞数、中性粒细胞比率及血脂等水平均无明显相关性。结论:ACS患者尤其是急性心肌梗死患者血MCP-1明显升高,SCF亦有所增加。MCP-1和SCF可能与ACS的发生发展及梗死后的心肌修复有关。

Objective：To investigate the changes of serum monocyte chemotactic protein-1（MCP-1） and stem cell factor（SCF） in patients with acute coronary syndrome（ACS） and theirs possible relationship with ACS.Method：41 patients with acute myocardial infarction（AMI）,45 patients with unstable angina（UA） and 32 controls were enrolled.The serum levels of MCP-1 and SCF were measured by ELISA in all subjects.Result：The serum levels of MCP-1 in AMI and UA patients were significantly higher than that in controls（P0.01 and P0.05）.The serum levels of SCF in AMI and UA patients were slightly higher than in controls,but there were not significantly different among three groups.The serum levels of MCP-1 and SCF in AMI patients were not related to white blood cells、neutrophil and blood fat.Conclusion：The serum level of MCP-1 in ACS patients,especialy in AMI patients,was significantly increase.The serum levels of SCF in ACS patients was slightly increase.MCP-1 and SCF might be associated with pathogenesis of ACS and cardiac repair after myocardial infarction.