摘要
目的:探讨血清胃蛋白酶原(PG)Ⅰ、PGⅡ、PGⅠ/PGⅡ、糖类相关抗原19-9(CA19-9)、癌胚抗原(CEA)在胃癌诊断及预后评估中的意义。方法:应用放射免疫测定法,检测60例胃癌病人和40例正常人的血清PGⅠ、PGⅡ、CA19-9以及CEA的值,并结合临床病理资料对结果进一步分析。结果:胃癌病人血清PGⅠ的值低于对照组,而CA19-9、CEA的值高于对照组,组间差异有统计学意义(P<0.05),胃癌病人血清PGⅠ、CA19-9的值与胃癌的不同临床分期有关(P<0.05),而血清CEA的水平只在Ⅰ、Ⅱ期与Ⅳ期间的差异有统计学意义(P<0.05)。胃癌病人血清PGⅠ、CA19-9、CEA的值与胃癌的淋巴结转移有关(P<0.05)。PGⅠ、PGⅡ和PGⅠ/PGⅡ的AUC分别为0.850、0.502和0.852,表明PGⅠ、PGⅠ/PGⅡ对胃癌的诊断价值较高,而PGⅡ对胃癌的诊断价值较低。结论:联合检测血清PG、CA19-9及CEA能够提高胃癌诊断的准确率,并且对胃癌的早期诊断有一定的临床应用价值。
Objective：To investigate the diagnosis and prognosis value of serum PGⅠ,PGⅡ,PGⅠ/PGⅡ,CA19-9 and CEA level for patients with gastric cancer.Methods：The contents of serum PGⅠ,PGⅡ,CA19-9 and CEA were detected by Radioimmunoassay in 60 patients with gastric cancer and 40 healthy people.Then the results were investigated combined with clinicopathological data.Results：The contents of serum PGⅠin gastric cancer group was significantly lower than the control group,while the contents of serum PGⅠand CA19-9 were higher than the control group（P〈0.05）.The contents of serum PGⅠand CA19-9 had statistical relatiuity with clinical stage（P〈0.05）,while the contents of serum CEA only had statistical relativity betweenⅠ,Ⅱ and Ⅳ stage（P〈0.05）.The contents of serum PGⅠ,CA19-9 and CEA had statistical relativity with lymph node metastasis（P〈0.05）.The AUC of PGⅠ、PGⅡand PGⅠ/PGⅡwere 0.850、0.502 and 0.852.It showed that PGⅠand PGⅠ/PGⅡ had a higher diagnostic value in gastric cancer,while the diagnostic value of PGⅡwas lower.Conclusion：The combined detection of serum PG,CA19-9 and CEA could improve the accuracy of diagnosing in gastric cancer.They had clinical application value for early gastric cancer diagnosis.
出处
《内蒙古医学院学报》
2011年第4期269-272,共4页
Acta Academiae Medicinae Neimongol
基金
内蒙古自治区自然科学基金(2006090618)
