Livin、survivin、caspase-3在子宫内膜异位症中的表达及其意义

Expressions and significance of livin,survivin and caspase-3 in endometriosis

目的研究Livin、survivin、caspase-3在子宫内膜异位症(endometriosis,EMs)中的表达,探讨其在EMs发病中的作用。方法采用原位杂交方法检测Livin在40例EMs在位内膜、异位内膜及25例正常子宫内膜中的含量,同时用二步法免疫组化的方法检测survivin、caspase-3在上述三组中的表达。结果 Livin、survivin在EMs异位内膜与EMs在位内膜的表达强于正常子宫内膜,其差异有统计学意义(P<0.05);caspase-3在EMs在位内膜与异位内膜的表达弱于正常子宫内膜,其差异有统计学意义(P<0.05);无论是EMs组还是正常对照组,Livin、survivin、caspase-3在月经增生期和分泌期表达强度差异无统计学意义(P>0.05)。结论子宫内膜异位症的发病可能与Livin、survivin、caspase-3的异常表达有关。

Objective To study the expression of livin, survivin and caspase -3 in endometriosis and its pathogenesis. Methods In situ hybridization was used to assess the content of Livin in normal endometrium （25 cases） , ectopic and eutopic endometrial tissues （40 cases）. Immunohistochemistry was used to assess the content of survivin and caspase -3 in the same tissues. Results The expression of livin, and survivin was stronger in endometriosis than in the control group, being of statistical significance（P 〈 0.05 ） , while the expression of caspase - 3 was weaker in endometriosis than in control group, being also of statistical significance（P 〈 0.05 ）. There was no significant difference between proliferative and secretory phases in all the three groups（P 〉 0. 05 ）. Conclusions The pathogenesis of endometriosis might be related to the abnormal expression of livin, survivin and caspase -3.