血浆Apelin-12、NT-proBNP在舒张性心力衰竭中的意义被引量：1

Significance of plasma apelin-12 and NT-proBNP in diastolic heart failure

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摘要目的:通过检测血浆Apelin-12(AP-12)、N末端脑钠尿肽原(NT-proBNP)在舒张性性心力衰竭(DHF)中的水平,探讨其在DHF中的价值。方法:选择72例DHF患者和30例心功能正常者(对照组),对比观察血浆AP-12、NT-proBNP水平及其与左室舒张功能指标的关系。结果:DHF患者血浆NT-proBNP水平明显高于对照组,并且其水平与心力衰竭的程度相关;而血浆AP-12水平则低于对照组。不同病因间血浆AP-12、NT-proBNP浓度无显著区别。结论:监测血浆AP-12、NT-proBNP水平对诊断DHF及判断其严重程度有一定的参考价值。 AIM： To investigate the value of plasma apelin-12 （AP-12） and NT-proBNP in diastolic heart failure （DHF） by measuring their levels. METHODS： Seventy-two DHF patients and 30 patients with normal heart function as the control group were included in the study. Levels of plasma AP-12 and NT-proBNP were compared, and their relationship with left ventricular diastolic function was analyzed. RESULTS ： The level of plasma NT-proBNP increased significantly in DHF compared with controls, and NT-proBNP showed progressive increases in proportion to cardiac dysfunction degree. Plasma AP-12 levels decreased in DHF compared with those in controls. There was no significant difference among DHF patients with different cardiac diseases. CONCLUSIONS： Plasma AP-12 and NT-proBNP concentrations increased in DHF patients compared with those in controls. Monitoring plasma AP-12 and NT-proBNP levels has some value in diagnosis and assessment of the severity of DHF.

作者李晓涛夏岳郭喜朝魏立业戚国庆

机构地区北京武警总队医院老年病科河北医科大学附属第一医院心内科

出处《心脏杂志》 CAS 2011年第4期498-501,共4页 Chinese Heart Journal

关键词舒张性心力衰竭 APELIN-12 N末端脑钠尿肽原 diastolic heart failure apelin-12 NT-proBNP

分类号 R541.62 [医药卫生—心血管疾病]

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