缬沙坦治疗不稳定型心绞痛的疗效和安全性

Clinical observation of valsartan in patients with unstable angina pectoris

目的：观察缬沙坦治疗不稳定型心绞痛（Unstable angina pectoris，UAP）的疗效及安全性。方法：选择UAP患者120例，随机分为常规组（60例）和缬沙坦组（60例）。常规组：常规治疗，包括硝酸酯类药物、阿司匹林、B．受体阻滞剂及他汀类药物，连续服药6个月，缬沙坦组在常规治疗的基础上加缬沙坦80—160mg，每天1次。观察治疗前后患者心绞痛临床症状的改善情况、心绞痛发作次数的改变、心电图sT段变化、血压变化及左心室肥厚的改变等情况。结果：治疗后，常规组和缬沙坦组心绞痛临床症状明显缓解，发作次数减少，ST－T段压低减轻，左心室肥厚明显逆转（均P〈0．05），缬沙坦组改善更显著（P〈0．05），两组患者的血压均明显下降（P〈0．05），但两组比较差异无统计学意义。结论：在UAP常规治疗的基础上，加用缬沙坦，对UAP治疗的疗效、安全性及耐受性均好。

AIM： To observe the curative effect and safety of valsarton on unstable angina pectoris （UAP）. METHODS： One hundred and twenty UAP patients were randomly divided into two groups： normal control group and valsartan group. For 6 months, patients in normal control group were given conventional treatment （nitrate acid ester, aspirin, β-receptor blocker and statins） and patients in valsartan group were given conventional treatment plus vaJsartan （40 -80 mg/qd ）. Changes in clinical symptoms of angina, anginal attack frequency, electrocardiogram of ST-T segment, blood pressure and left ventricular hypertrophy were observed. RESULTS： Clinical symptoms of angina in the two groups were assuaged, attack frequency decreased, ST depression was reduced and left ventricular hypertrophy was reversed （ P 〈 0. 05 ）. Blood pressure of the two groups decreased （ P 〈 0. 05 ） but with no significant difference between groups. CONCLUSION： On the basis of conventional therapy, valsartan has a reliable curative effect, good safety, more tolerance and few side effects in treatment of patients with UAP.