伴有慢性支气管炎症老年患者颈动脉硬化病变与冠状动脉病变有相关性

Relationship between carotid artery atherosclerosis and coronary heart disease in elderly patients with chronic bronchitis

目的:应用多普勒超声分析伴有慢性支气管炎的心绞痛患者颈动脉病变,并分析与冠心病病变的相关性。方法:选择因心绞痛行冠状动脉造影的患者328例,根据造影结果分为对照组80例、单支病变组102例、2支病变组62例和多支病变组84例。测量颈总动脉内膜中层厚度(IMT)及颈动脉分叉处IMT,记录颈动脉斑块的位置、数量。结果:颈总动脉IMT、分叉部IMT、斑块积分组间差异有统计学意义(P<0.05,P<0.01)。颈总动脉IMT多支病变组与对照组(P<0.01)、2支病变组与对照组(P<0.05)、单支病变组与多支病变组(P<0.01)差异有统计学意义,其余组间两两比较无统计学差异。分叉部IMT,单支病变组与对照组差异无统计学意义,其余各组两两之间比较均有统计学差异(P<0.01,P<0.05)。斑块积分,多支病变组与2支病变组间差异无统计学意义,其余组间两两比较均有统计学差异(P<0.01,P<0.05)。颈动脉IMT、分叉部IMT、斑块积分相关系数均有统计学意义(P<0.05)。结论:伴有慢性支气管炎的老年颈动脉粥样硬化与其冠状动脉病变有相关性。

AIM： To investigate whether the extent of carotid atherosclerosis is associated with coronary heart disease （CHD） in elderly patients with chronic bronchitis. METHODS： Carotid ultrasound was per- formed in 328 patients. According to the results of coronary angiography, patients were divided into four groups ： one-vessel group （ n = 102）, two-vessel group （ n = 62）, multi-vessel group （ n = 84） and normal control group （n =80）. The intima-media thickness （IMT） and the degree of carotid atherosclerosis were compared among the four groups. RESULTS： A statistically significant difference in carotid artery IMT and plaque score was observed between control group and coronary artery disease （CAD） groups （P 〈 0. 05）, especially between two-vessel and muhivessel groups. CONCLUSION： Our findings indicate that carotid atherosclerosis is a good predictive marker for coronary heart disease. Ultrasound examination of the carotid artery is of some value in screening high-risk patients with coronary artery disease.