摘要
目的探讨喉神经内分泌癌的临床表现,并对其诊断及治疗进行探讨。方法对2例喉神经内分泌癌临床表现、病理、诊断、治疗和预后进行回顾性分析。结果 2例肿瘤均位于声门上区,直径<2 cm,病变局限,非浸润性生长,与周围组织边界清晰。术前依靠病理确诊,采取喉部分切除,1例随访6年,未见复发及转移;另1例仍在随访中。结论喉神经内分泌癌是一种较为罕见的恶性肿瘤,正确诊断有赖于临床症状、体征、组织病理学及免疫组织化学检查。熟悉其临床特征,对术前正确诊断、术中术式的选择及术后放疗、化疗的配合应用和提高患者术后生存率有重要意义。
Objective To investigate the clinical characteristics,diagnosis and treatment of laryngeal neuroendocrine carcinoma（LNEC）.Methods The clinical manifestations,pathological features,diagnosis,treatment and prognosis of two patients with LNEC were analyzed retrospectively.Results The solitary tumors in the two cases were localized in the supraglottic region,with the diametars less than 2 cm.Partial laryngectomy was performed in both cases after preoperative patholgical confirmation.One case has been following up for 6 years without recurrence and the other is in follow-up.Conclusion LNEC is a rarely malignant tumor and the correct diagnosis relies on clinical characteristics,objective sign,histopathological feature and immunohistochemical examination.To be familiar with the clinical characteristics has important significance in the preoperative diagnosis,selection of operative mode,combination of postoperative radiotherapy and chemotherapy and improvement of postoperative survival rate of the patient.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
2011年第3期196-198,203,共4页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
关键词
喉神经内分泌癌
诊断
治疗
Laryngeal neuroendocrine carcinoma
Diagnosis
Treatment
