菌毒清颗粒的急性毒性研究

Study on acute toxicity test of juduqing granule

目的研究菌毒清颗粒安全性,为临床安全用药提供一定的参考。方法采用最大给药量法观察菌毒清颗粒的急性毒性反应。结果菌毒清颗粒在(91.17g/kg)灌胃给药后,连续观察14d,未观察到小鼠出现毒性症状,无小鼠死亡,LD50>91.17g/kg体重。结论菌毒清颗粒具有较高的安全性。

Objective To study on safety of Juduqing granule,in order to provide some references for clinical drug use.Methods The maximum dose for mice was determined by the acute toxicity test of Juduqing granule.Results No toxicity effect was observed at dose of 91·17 g/kg·bw.Conclusion Juduqing granule is proven to be safe t in rats.