肌钙蛋白I、脑钠肽和C-反应蛋白水平与急性心肌梗死关系的临床研究

Clinical Study of Relationship between Acute Myocardial Infarction and Plasma Levels of cTnI,BNP and CRP

目的探讨血浆心肌肌钙蛋白(cardiac troponin I,cTnI)、脑钠肽(brain,natriuretic peptide BNP)和C反应蛋白(C-reactive protein,CRP)水平与急性心肌梗死(acute myocardial infarction,AMI)病情及预后的关系.方法测定103例AMI患者入院时血浆cTnI、BNP和CRP含量,与同期93例健康体检者(对照组)血浆cTnI、BNP和CRP进行对照.结果 (1)AMI患者和对照组血浆中cTnIc,BNP和CRP水平性别间无差异;(2)AMI患者的cTnIc,BNP和CRP均明显高于正常组;(3)AMI导致总心脏事件发生的病人cTnI和BNP明显高于治愈者.结论 cTnI、BNP与CRP是AMI的敏感指标,这些指标的水平与心血管病变程度,尤其是急性心肌梗死密切相关.

Objective To investigate the relationship between plasma levels of cardiac troponin I（CTnI）,brain natriuretic peptide（BNP）and C-reactive protein（CRP）and the severity and prognosis of acute myocardial infarction（AMI）.Method The plasma levels of cTnIc,BNP and CRP of 103 patients with acute myocardial infarction（AMI）were detected within 12～18 h after chest pain,and compared with 93 healthy persons as contorl.Results（1）The differences in the plasma levels of cTnIc,BNP and CRP of patients between genders were not statistically significant;（2）The plasma levels of cTnI,BNP and CRP of patients in AMI group were all higher than those in control group;（3）The plasma levels of cTnI and BNP of patients with incidence of cardiac events were higher than cured patients.Conclusion cTnI,BNP and CRP have high sensitivity in AMI patients and their levels are closely related with cardiovascular disease,especially for acute myocardial infarction.