术前应用质子泵抑制剂对内镜超声引导下细针穿刺所致菌血症发生率的影响

The influence of proton pump inhibitors on incidence of bacteremia after endoscopic ultrasonography guided fine needle aspiration

目的观察内镜超声引导下细针穿刺术前应用质子泵抑制剂是否易导致术后菌血症的发生。方法将18只实验犬随机分成两组，实验组8只，对照组10只。实验组术前3d食物中予奥美拉唑20mg，每日2次，对照组空白对照，并以胰腺为穿刺目标进行穿刺，穿刺前后取血标本进行细菌培养，比较两组菌血症发生率。结果共11只实验犬血样细菌培养出现阳性，在排除污染的情况下，实验组1只和对照组3只实验犬为真性菌血症，经Fisher检验，两组菌血症的发生率差异无统计学意义（P=0．383）。结论术前应用抑酸药物没有增加菌血症的发生。

Objective To investigate whether preoperative proton pump inhibitor （PPI） would in- crease the risk of bacteremia after endoscopic uhrasonography guided fine needle aspiration （EUS-FNA）. Methods Dogs were randomly divided into experimental group （n = 8） to take 20mg of omeprazole orally twice a day for 3 days before EUS-ENA, and control group （ n = 10） to take placebo. EUS-FNA was performed to puncture the pancreas, and blood was collected before and after the procedure for culture. Bacteremia incidence of the two groups were compared. Results Bacteria culture was positive in 11 edogse. After excluding contamination, 1 dog in experimental group and 3 in control group were authentical bacteremia. There was no significant difference on the incidence of bacteremia between 2 groups based on Fisher test （ P = 0. 383 ）. Conclusion Aplication of PPI before EUS-FNA is not likely to increase the incidence of bacteremia.