颗粒状角化不全

Granular parakeratosis:report of two cases

报告2例颗粒状角化不全。患者分别为22岁女性和39岁男性,左腋窝角化性丘疹伴瘙痒10余年和18年。组织病理检查示角质层角化过度及角化不全,伴有明显嗜碱性透明角质颗粒沉积。诊断:颗粒状角化不全。

Two cases of granular parakeratosis are reported. A 22-year-old female and a 39-year-old male presented with crusted, hyperkeratotic, hyperpigmented and itchy papules and plaques on the left axillae for more than 10 years and 15 years respectively. The histopathologic examination showed a thickened stratum corneum with compact parakeratosis, slight epidermal hyperplasia, and a sparse perivascular lymphohistiocytic infiltration. Diffuse keratohyalin granules were within the parakeratotic stratum corneum, and the retained granular layer showed focal vacuolization. No fungi were seen with the PAS stain. The diagnosis was made as granular parakeratosis.