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糖尿病胃轻瘫患者胰高糖素样肽-1及其受体表达与胃排空的关系 被引量:2

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摘要 糖尿病胃轻瘫(diabetic gastroparesis,DGP)指糖尿病患者在无机械梗阻情况下并发的胃动力障碍或胃排空延迟,典型临床表现为腹痛、腹胀、恶心、呕吐、早饱、食欲不振。胰高糖素样肽-1(glucagon like peptide-1,GLP-1)是一种新的肠促胰岛素,具有促进胰岛素合成及分泌、抑制胰高糖素分泌、延缓胃排空、抑制胃酸分泌等生物学作用[1]
出处 《中华消化杂志》 CAS CSCD 北大核心 2011年第6期405-406,共2页 Chinese Journal of Digestion
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参考文献5

  • 1Steinert RE, Poller B, Castelli MC, et al. Orally administered glucagon-like peptide-1 affects glucose homeostasis following an oral glucose tolerance test in healthy male subiects. Ciin Pharmacol Ther, 2009, 86:644-650.
  • 2Schirra J, Houck P, Wank U, et al. Effects of glucagon-like peptide-1(7-36)amide on antrO-pyloro-duodenaI motility in the interdigestive state and with duodenal lipid perfusion in humans. Gut, 2000,46:622-631.
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同被引文献30

  • 1张泓,严洁,易受乡,常小荣,刘玉群,林亚平,阳仁达.电针足阳明经穴对胃窦胆囊收缩素受体基因表达的影响[J].中国针灸,2004,24(10):717-719. 被引量:7
  • 2杨朝民,贾静,杜宪一.针刺梁门穴对胃病患者胃电的影响[J].陕西中医,1993,14(7):318-319. 被引量:6
  • 3庄礼兴,陈楚云,郭跃峰.针刺与西药治疗糖尿病胃轻瘫的对照研究[J].中国针灸,2005,25(4):249-251. 被引量:31
  • 4Shiko A, Takuyuki K, Naoko O, et al. No ghrelin response to oral glucose in diabetes mellitus with gastroparesis [J]. Endo crine J,2009,56(1):79-87.
  • 5Onoma M, Ozaki K, Yogo K, et al. Mitemcinal (GM 611), an orally active motilin receptor agonist, improves delayed gas- tric emptying in a canine model of diabetic gastroparesis[J]. Clin Exp Pharmacol Physiol, 2008,35(7) :788-796.
  • 6Hosoda H, Kojma M, Masuo H, et al. Ghrelin and desacy ghrelin:two major forms of rat ghrelin peptide in gastrointesti nal tissue [J]. Biochem Biophys Res Commun, 2000, 279 909-913.
  • 7Gnanapavan S, Kola B, Bustins A, et al. The tissue distribu tion of the mRNA of ghrelin and subtypes of its receptor GHS-R,in humans[J]. Clin Endocrinol Metabol, 2002,87 (6) :2988.
  • 8Warzecha Z, Dembinski A. Protective and therapeutic effects of ghrelin in the gut[J]. Curr Med Chem, 2012,19(1):118 -125.
  • 9Yang C G, Liao Z F, Qiu W C, et al. Function of ghrelin and ghrelin receptors in the network regulation of gastric motility [J]. MolMed Rep,2014,10(5);2453-2458.
  • 10Mushy K" S, Zhang K M, Jin J G, et al. VIP-mediated and G-Protein-coupled Ca2+ influx activates a constitutive NOS in dispersed gastric muscle cells[J]. Am J Physiol, 1993,265 (4 Pt 1): G 660-671.

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