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C57BL/6小鼠在烧伤及药理学实验中的Meeh常数取值

Calculation of a Meeh constant during thermal injury and pharmacology experiments in C57BL/6 mouse
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摘要 目的研究在烧伤及药理学实验中计算C57BL/6小鼠全身体表面积(BSA)时Meeh常数(k)的取值。方法测量20只C57BL/6小鼠的体重和BSA,并计算出小鼠的实际k值,比较其与5个正常小鼠常用k值(6.0、9.1、9.5、10.0和11.4)间的差异。结果小鼠BSA计算所得的k值为9.715±0.142,与正常小鼠常用k值比较差异均有统计学意义(P<0.01)。结论应用Meeh公式计算C57BL/6小鼠的BSA时,k值宜选用9.715。 Objective To investigate the proper Meeh constant（k） for calculating the body surface area（BSA） of C57BL/6 mouse in the experiments of burn and pharmacology study.MethodsThe body weight and BSA of twenty C57BL/6 mice were measured.The k value of each mouse was calculated and compared with the five common k values （6.0,9.1,9.5,10.0 and 11.4） in normal mice.Results The calculated k value in this group was 9.715±0.142,which was significantly different from the five frequently-used k values（P0.01）.Conclusion A k value of 9.715 should be taken for calculating the BSA of C57BL/6 mouse.
作者 廖庚进 付晋凤 罗鹏飞 贾一韬 孙瑜 金以超 夏照帆
机构地区 昆明医学院第二附属医院烧伤科 上海第二军医大学长海医院烧伤科
出处 《江苏医药》 CAS CSCD 北大核心 2011年第14期1626-1628,共3页 Jiangsu Medical Journal
基金 国家自然科学基金重点项目(30730091)
关键词 烧伤 体表面积 Meeh常数 Burn Body surface area Meeh constant
分类号 R644 [医药卫生—外科学]
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参考文献8

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江苏医药
2011年 第14期

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