摘要
1例41岁男性,间断吸食苯丙胺类兴奋剂麻古(主要含有甲基苯丙胺和咖啡因)2年余,1年前开始自行减少剂量,就诊前4周完全停止吸食。戒断15d患者出现昼间嗜睡,频繁发作,10～20min发作1次,每次持续数分钟至数十分钟,并多次出现"梦魇"现象。多导睡眠图示平均睡眠潜伏期缩短至80s。诊断为发作性睡病,考虑为停用麻古所致。鼓励患者继续坚持戒断,增加体力活动和视听刺激,以避免白天睡眠。给予阿米替林25mg晚间睡前口服。2周后,患者睡眠障碍消失。
A 41-year-old man took a amphetamine-type stimulant Magu （mainly containing methamphetamine and caffeine） intermittently for more than 2 years. One year ago, he began to reduce the dose of Magu himself and then to stop taking Magu completely 4 weeks before he presented himself to clinic. Fifty days after Magu withdrawal, he developed daytime sleepiness, which occurred frequently; each episode occurre：l within 10-20 min and lasted for a few minutes to tens minutes. He experienced ＂nightmare＂ phenomenon several times. Polysomnography revealed that a mean sleep latency decreased to 80 seconds. Narcolepsy was diagnosed, which was considered to be induced by Magu withdrawal. The patient was encouraged to insist on the drug withdrawal and to enhance physical activities as well as audio-visual stimuli for avoiding daytime sleep. He was given oral amitriptyline 25 mg before going to sleep at night. Two weeks later, the patient＇s sleep disturbances disappeared.
出处
《药物不良反应杂志》
2011年第3期171-172,共2页
Adverse Drug Reactions Journal
